HOST-PATHOGEN SYSTEMS AND EXPERIMENTAL GENETICS BIOLOGIST FULL TIME ASSISTANT ADJUNCT PROFESSOR
The Department of Cellular and Molecular Pharmacology (CMP) at the University of California, San Francisco is recruiting a basic science researcher for a full-time Assistant Adjunct Professor position. The selected candidate will join the Host-Pathogen Mapping Initiative (HPMI) (hmpi.ucsf.edu), a multi-disciplinary team of systems and structural biologists, as well as infectious disease experts and clinicians, with the goal of exploring the molecular details that define pathogen virulence and host immunity. The HPMI group aims to systematically map the physical and genetic interaction networks for a variety of diverse infectious pathogens, and ultimately integrate the network, structure, and functional data within and across disease platforms to identify common biological pathways and complexes in the host that can be therapeutically targeted with potential broad-spectrum activity.
The successful candidate will lead the proteomic efforts for HPMI, including large-scale protein-protein interaction (PPI) studies, Cas9-based knockout studies, and genetic interaction studies investigating host-pathogen protein complexes and networks. As an independent investigator, the candidate will: (1) perform proteomics experiments; (2) analyze proteomic data (3) develop and implement new experimental genetics workflows in cultured and primary systems; (4) provide scientific oversight of the project including review and advice on experimental design, data interpretation, and long-term planning to her or his team and colleagues; and (5) write manuscripts and applications for federally sponsored research. This position will also contribute significantly to other infections disease priorities, such as the QBI Coronavirus Research Group, and others.
The applicant must have a PhD and/or MD degree in systems biology, biochemistry or a related field, and a strong track record of developing and leveraging innovative proteomic-based systems or structure research, with emphasis on host-pathogen interactions preferred. Candidates must have research expertise in developing and applying RNAi and Cas9-based genetic approaches, genetic interaction mapping, and mapping protein interaction networks. Experience with data analysis tools such as R and Python is preferred.
A strong research record is essential, including evidence of publishing in high impact peer-reviewed journals and experience in writing and submitting proposals for federally sponsored research. Applicants will have strong written, verbal, and presentation skills and an ability to communicate and work in an interdisciplinary team environment. In addition, she or he should have excellent management skills with experience mentoring and advising students and trainees.
Extensive experience with molecular biology lab techniques and cell culture
CRISPR/Cas9 gene editing in cultured and primary cell types
Genetic interaction mapping
Protein interaction mapping
Experience in BSL3 handling infectious material.
Proteomic data analyses
Demonstrated experience as a research project lead
Manage multiple diverse and collaborative projects between multiple laboratories
Excellent oral and written communication skills
High productivity and successful record publishing in high impact journals
Unix / Linux command line
Data analysis using R or Python
Success in securing external research funding
UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.