Research - Laboratory/Non-Laboratory, Staff/Administrative
The Department of Laboratory Medicine and Pathology serves as a regional resource for clinical laboratory services required for patient care, research and educational programs in laboratory medicine and pathology. The department now employs 900 people who work at the award-winning University of Washington Medical Center (ranked among the top medical centers in the United States as rated by U.S. News & World Report), Harborview Medical Center (the region's only Level I Trauma center, known for innovations and excellence in trauma care and its centers of emphasis: Trauma, Burn, Neurosciences, AIDS/STD CARER, and mentally- and medically- vulnerable populations.), and many other clinical and research facilities in the area. The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement and natural beauty.
Our LABORATORY MEDICINE AND PATHOLOGY DEPARTMENT has an outstanding full-time position for a Variant Review Scientist in the field of genetics with a focus on cancer diagnostics. This individual will work as a genetic variant review scientist to review and interpret genetic variants from molecular testing and assist laboratory directors with interpretation and reporting of exciting new genomic-based diagnostic testing in genetics, with a focus on next-generation sequencing oncology diagnostics and inherited disorders. This includes the review of UW-OncoPlex, BROCA, complex genetic panels, exomes, clinical genomes, and other advanced diagnostic testing applied to large research studies supported by the Genetics Division of Laboratory Medicine and Pathology, reviewing research genetic testing results, providing expert interpretation, and developing novel methods and techniques to analyze data.
The person in this role will analyze complex NGS datasets to interpret variants and synthesize interpretive reports. The scientist will work directly with faculty in the genetics division to assist with data analysis. The scientist will also work with laboratory genetic counselors, bioinformaticists, and laboratory staff to help interpret data.
Generates data and responsible for review and interpretation of genomic test results under direction of clinical laboratory directors.
Provide analysis and consultant to physicians and scientists in other departments as needed to guide development, implementation and interpretation of genomic test services.
Review patient medical history to determine eligibility for NGS testing.
Write patient reports for review by oncology and pathology clients, Neurology, and other healthcare speciality clients.
Interpret data from high complexity genomic techniques including next generation sequencing and arrays.
Develop and coordinate data analysis strategies and implementation for large research projects.
Develop relationships and independently consult experts in the field to assist with interpretation of challenging variants.
Development and Maintenance:
Responsible to review genomic data and maintain the active knowledge-base for variant interpretation.
Update variant curation strategies, variant scoring process, interpretation process, and reporting process on an on-going basis.
Develop expertise in interpreting genetic data from open source and proprietary analysis software and databases.
Design of tools to assist in more efficient variant review for the variant review scientist and affiliated faculty.
Responsible for extensive literature review and provide consult, input and collaborates in interdepartmental journal clubs for ongoing education.
Responsible to generate, develop, and provide data at client meetings and conferences, when required.
Requirements: Master’s Degree in Genetics, Genomics, Molecular Biology, Chemistry, Biochemistry, or related discipline, and two to three years of relevant experience.
An equivalent combination of education and experience may substitute for stated requirements.
Experience in molecular biology methods and data analysis.
Strong teamwork, interpersonal, and managerial skills.
Strong organizational and documentation skills suitable to a clinical laboratory environment. Demonstrates ability to rapidly distill concise and succinct summaries from complex and potentially contradictory literature sources.
Comfortable using a variety of computational databases to aid in the interpretation of genomic variants.
Ability to work independently. Ability to prioritize and work under tight deadlines.
Excellent verbal and written communication and organizational skills.
Ph.D. in genetics, genomics, molecular biology, chemistry, biochemistry, or related discipline.
Previous experience working in a diagnostic laboratory, with experience reviewing medical literature and pathology reports.
Experience with next-generation sequencing methods and data analysis.
Experience in genetic variant interpretation for oncology-based, exome, and clinical genomeNGS tests.
This position provides opportunities to work in a fast-paced, challenging, diverse and rewarding environment. As an employee you will enjoy generous benefits and work/life programs. For detailed information on Benefits for this position, click here.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.