Junior Specialist – Aghi Lab Department of Neurological Surgery University of California, San Francisco
The person filling this position will participate in basic science research to study mechanisms of glioblastoma angiogenesis, mechanisms of resistance to currently used anti-angiogenic therapies, and what drug combinations are best suited to inhibit glioblastoma angiogenesis in mouse models of human glioblastomas. Job duties will include extraction of RNA and DNA form human glioblastoma tissue; immunohistochemistry and immunofluorescence of glioblastoma tissue and cultured primary glioblastoma cells; isolation of cells from glioblastoma tumors and flow cytometry of the cells to count numbers of various cell types; isolation of stem cells from human glioblastomas; CRISPR techniques; and intracranial and subcutaneous implantation of tumor cells into immunodeficient mice, followed by treatment and monitoring of these animals and euthanasia when appropriate. Also handles lab administration - order entry, making sure protocols are in compliance, and orienting new lab members. Other duties as assigned.
Required Qualifications: • Specialists appointed at the junior rank must possess (or be in process of obtaining) a baccalaureate degree or must have at least four years of research experience. • Applicant’s materials must list (pending) qualifications upon submission. • Applicants must have obtained the degree requirement for the junior specialist rank by the time of hire. • Experience with basic wet lab research (cell culture, pipetting, sectioning tissue, immunostaining, qPCR, mouse tumor implantation, western bloitting) • Ability to learn more advanced wet lab techniques (CRISPR, immunoprecipitation, purification of histidine-tagged proteins). • Ability to independently plan experiments from start to finish to address a specific topic, ultimately leading the person filling this position to write portions of manuscripts • Ability to handle lab administration, including order entry, making sure protocols are in compliance, and orienting new lab members.
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.
UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.