A position for a highly motivated postdoc is available in the Israely Lab at Columbia University's Irving Medical Center in the city of New York. We are a part of the Department of Pathology & Cell Biology and the Department of Neuroscience (located in the Taub Institute on Alzheimer's Disease and the Aging Brain). Our research aims to understand how activity leads to functional and structural alterations in neuronal microcircuits which allow for learning and memory. The long lasting storage of information requires activation of local signaling events, recruitment of new protein synthesis, and induction of structural changes which together support changes in synaptic efficacy that can last a lifetime. The successful candidate will join us in applying advanced optical methods (such as 2-photon microscopy, glutamate uncaging, and calcium imaging) to manipulate and follow activity at single or groups of spines in living neurons ex vivo. We will probe local hippocampal (and other) circuits with light and electrophysiological approaches, employ various biochemical methods and fluorescent reporters, and leverage the power of genetics to test these questions in mouse models of neurodevelopmental disorders and neurodegeneration. By achieving a fundamental understanding of the learning rules in neurons, we hope to also elucidate critical points of dysfunction which impact learning and memory across human cognitive disorders.
Internal Number: 6700
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.