Within the framework of the NIGMS (R01)-funded project “Investigation of the role of UNC-45A in Paclitaxel-mediated microtubule stability” a postdoctoral position is available to study the role of the recently identified microtubule destabilizing protein UNC-45A in the contest of chemoresistance and in neurodegenerative diseases. This is a collaboration between the lab of Dr. Bazzaro at the Masonic Cancer Center of the University of Minnesota and Dr. Odde at the Department of Biomedical Engineering at the University of Minnesota. For the longest time, cancer and neurodegenerative diseases have been considered at the opposite end of the spectrum of human diseases. That is because cancer is characterized by highly dividing cells that resist death while neurodegenerative diseases are generally characterized by death of post-mitotic cells. Today, genetic and cell biology studies show multiple common pathways in cancer and neurodegeneration. This includes pathways that regulate microtubule stability in cells.
The project will explore the mechanisms through which UNC-45A, a novel Microtubule-Associated-Protein and regulator of paclitaxel sensitivity in human cancer cells, regulates microtubule dynamic in vitro (reconstituted microtubules,) in living cells (cancer cells and neurons) and in human clinical specimens of cancer and Alzheimer's disease (AD).
Study the role of the recently identified microtubule destabilizing protein UNC-45A in the contest of chemoresistance and in neurodegenerative diseases.
Assists post-docs and other scientific staff with experiments 35%
Data Management 35%
Assist with study procedures under direction and collaboration with Lab Manager and PI 15%
Administrative and Other Duties 15%
Ph.D. in cell biology, biochemical engineering, neuroscience, biochemistry, or related field
Proven productivity with at least one first author publication.
Expertise in live-cell fluorescent imaging, confocal microscopy, SDS-PAGE, Western blotting, immunohistochemistry, invasion and migration assay along with an interest in studying microtubule dynamics, human cancer and neurodegenerative diseases.
Proficient in Microsoft Office, Excel, Powerpoint, and graphing programs such as Prism.
Attentive and reliable with various modes of communication (email, texts) and must have motivation to pursue and drive a project independently.
Basic experience with programming, statistical analysis, or bioinformatics analysis.
Internal Number: 335162
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