Research - Laboratory/Non-Laboratory, Staff/Administrative
Lab Manager (9611C) 14708
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Application Review Date
The First Review Date for this job is: February 8, 2021
The Roelink Lab is seeking a Lab Manager to support the study of mechanisms of embryonic induction, the phenomenon in which a group of cells changes the developmental fate of neighboring cells via the release of inducers and other molecules. The molecular nature of these inducers is known and they belong to a relatively small number of families of signaling proteins. Invariably proteins molecules are involved both in the maintenance or differentiation of adult stem cells as well as in cancer. We are particularly interested in Sonic Hedgehog (Shh) and members of the BMP and Wnt families.
By combining genomic engineering using TALENs and CRISPR/Cas9 with stem cell differentiation into neural tissue, we study the autonomous and non-autonomous consequences of mutating proximal elements in the Sonic Hedgehog response pathway.
Carry out independent scientific work addressing the intrinsic peptidase function of the signaling molecule Sonic Hedgehog
Additional scientific work analyzing Sonic Hedgehog function in genome edited mosaic neural organoids
Generation of cell lines and studies to test the association to the ECM of mutated form of Sonic Hedgehog.
Carry out biochemical experiments addressing the composition of the ECM in cell lines and organoids
Advise students, postdocs and SRA I and oversee procedures including DNA cloning, DNA and protein purifications, cell culture, and microscopy.
Contribute to the drafting of manuscripts and generation of figures
Supervision of SRA I and LA IIs and other lab staff including students and postdocs
Supervise work duties and ensure tasks are performed appropriately; post hiring requests, interview, help select and train lower level staff.
Train SRA I and lab research staff in; biochemical purifications of antibodies, animal surgical techniques, procedures to order and manage chemical inventory, cell line/antibody repositories, and lab shipments to other laboratories, and safety and lab regulations.
General Lab Management
Manage staff and lab personnel in carrying out ordering, management of inventories, lab shipments, and following proper procedures.
Essentially making sure everything is in it's right place and arranged in a way that is conducive to laboratory use
General Lab Purchases - enter purchases on website and submit approvals
Ensure adequate levels of all supplies are available
Special Purchases - Obtaining quotes and completing sole source justifications
Chemical, and Biological Hazardous Material Management
Safety Training of new hires and when additional training of lab members is requested.
Lab Safety Inspection once a year,
Communicate with EH&S, ACUC, OLAC about hazardous issue, inspections, training, addition and removal of lab members, help PI with updating the RUA, BUA and AUP
Update SOPs and ensure everyone doing the relevant experiments had read and signed.
Report new and recurring hazards to lab members during lab meeting
Manage and curate the cell line collection
Preparation and updates of Standard Operating Procedures and Biological Use Authorizations
Draft all protocols and authorization paperwork
Interact with staff of ACUC and EHS for finalizing protocols
Proven ability to purify proteins, and assess functional activities of proteins.
Proven ability to perform all aspects of tissue culture, including stem cells
Proven ability to use and supervise the use microscopy to visualize the localization of labeled and fluorescent proteins
Proven ability to supervise SRAs and Lab assistants in managing and stocking the lab.
Proven ability to manage a postdocs, graduate students and SRAs.
Education/Training: BA, BS, or PhD in a related field and/or equivalent combination of education/experience.
Incumbents are expected to possess the skills, knowledge and abilities essential to the successful performance of the duties assigned to the positions. These skills, knowledge, and abilities are typically acquired through a combination of extensive study and experience.
Salary & Benefits
This a monthly paid (exempt) position. Annual salary will be commensurate with experience.
For information on the comprehensive benefits package offered by the University visit:
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