The Department of Neurosurgery and the Neurovascular Laboratory of Dr. Gonzalez at Cedars-Sinai Medical Center are seeking a highly motivated and talented Postdoctoral Researcher to lead new neurovascular research projects for conditions affecting the cerebral vasculature of patients with neurological and neurosurgical conditions throughout the training period.
Our Postdoctoral Scientist will work with a multidisciplinary team of expert neuroscientists, neuroimagers, neurologists and neurosurgeons to investigate the mechanisms of angiogenesis and arteriogenesis in the central nervous system in patients suffering from cerebrovascular disorders including stroke, moyamoya disease, intracranial atherosclerosis, intracranial aneurysms, and vascular malformations. You will be primarily based in the group of Dr. Gonzalez with access to appropriate Neurovascular Laboratory facilities and shared resources of the Neurosciences Laboratories at Cedars Sinai, as well as exciting new opportunities for human tissue access by participating in existing and future, multicenter clinical trials led by Dr. Gonzalez. Working independently and in close cooperation with Dr. Gonzalez and other Research Scientist. You may develop, adapt, and implement new research techniques and protocols; analyze and interpret data; may assist in preparation of grant proposals; and participate in publications and presentations as author or co-author. Will not responsible for generating grant funds.
May participate in publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
May develop, adapt, and implement new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
May submit own grants or assist in preparation of grant proposals but is not responsible for generating grant funds.
Will develop, adapt, and implement experiments in tissues and small animal models for evaluation of cerebra angiogenesis and arteriogenesis in ischemic conditions.
Will apply and develop techniques for evaluation of neuronal survival, blood brain barrier disruption, and inflammatory response to cerebrovascular ischemia in small animal models.
Will apply and develop techniques for analysis of human tissues for evaluation of angiogenic factors, exosomal isolation, and micro RNA extraction.
PhD in Vascular Biology, Neurosciences, Biomedical Science or a related field is required
At least two (2) years of hands-on experience with the design, execution, and analysis of cellular, molecular, and/or biochemical assays focused on angiogenesis, neuronal survival, blood brain barrier disruption and inflammatory responses in vitro and in vivo.
Technical skills should include experience with most or all of the following: PCR, RT-PCR, ELISA, Luminex, cell-based assay development (e.g. cellular cytotoxicity, proliferation, reporter, ligand binding, etc. with multiple readouts), FACS, Western blotting, immunocytochemistry, and immunohistochemistry.
Works independently on research projects designed by one or more mentors within area of specialization. Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment. Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection and analysis and operation and maintenance of specialized equipment. Knowledge of safety standards of specialized equipment. Has excellent problem-solving, interpersonal, communication, self- and time-management skills, and the ability to work effectively both in a team and independently.
Desirable but not required experience with small animal models of cerebral ischemia, such as MCAO (permanent and with reperfusion) carotid ligation and chronic carotid stenosis.
Working Title: Postdoctoral Scientist - Department of Neurosurgery - Gonzalez Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.