Description of Duties: Postdoctoral researcher will perform experiments related to the mechanisms of vitamin B6 (PLP) dependent enzymes. The experiments are largely kinetic in nature. Computational (molecular dynamics) calculations will also be a significant component of the work. The project involves connecting protein motions to enzyme catalysis by measuring the activation heat capacity change (deltaCp?) and calculating the same quantity by molecular dynamics.The researcher will also lead the lab safety compliance effort, interact directly with collaborators, mentor undergraduate and graduate students, and generally be the leader of the lab environment.
Qualifications: PhD or equivalent required. Must have experience performing rapid reaction (stopped-flow, etc) and steady-state enzyme kinetic measurements. Experience expressing proteins in E coli and their purification necessary. Experience in optical spectroscopy and structural biology a plus.
UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we’ve been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society.Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive.