Research Support - Laboratory/Non-Laboratory, Staff/Administrative
HTS Research Associate/Scientist (7118U) 18031
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The University of California, Berkeley, is one of the world's leading institutions of higher education, distinguished by its combination of internationally recognized academic and research excellence; the transformative opportunity it provides to a large and diverse student body; its public mission and commitment to equity and social justice; and its roots in the California experience, animated by such values as innovation, questioning the status quo, and respect for the environment and nature. Since its founding in 1868, Berkeley has fueled a perpetual renaissance, generating unparalleled intellectual, economic and social value in California, the United States and the world.
We are looking for equity-minded applicants who represent the full diversity of California and who demonstrate a sensitivity to and understanding of the diverse academic, socioeconomic, cultural, disability, gender identity, sexual orientation, and ethnic backgrounds present in our community. When you join the team at Berkeley, you can expect to be part of an inclusive, innovative and equity-focused community that approaches higher education as a matter of social justice that requires broad collaboration among faculty, staff, students and community partners. In deciding whether to apply for a position at Berkeley, you are strongly encouraged to consider whether your values align with our Guiding Values and Principles, our Principles of Community, and our Strategic Plan.
Application Review Date
The First Review Date for this job is: May 15, 2021
The Henry Wheeler Center for Emerging & Neglected Diseases (CEND) was established as a multi-disciplinary research unit in 2008, with the support of a generous donation by Henry H. Sam Wheeler, Jr. The mission of CEND is to help the University of California, Berkeley make innovative and substantial contributions to the global response to emerging and neglected infectious diseases. We at CEND believe that by educating potential innovators, connecting researchers from diverse disciplines, and investing in research, we can help the best and brightest minds at UC Berkeley access the resources they need to make meaningful and innovative contributions to our scientific understanding and ability to combat emerging and neglected diseases.
We are looking for a motivated, reliable Research Associate / Entry level scientist to conduct assay development and small molecule screening at the Drug Discovery Center at UC Berkeley, with the goal of finding compounds useful in neurodegenerative, infectious and other diseases. The position reports to the Drug Discovery Center lead scientist, Eddie Wehri. The High Throughput Screening Engineer will work with a world-class team of faculty and scientists, learning the design and implementation of HTS assays such as robust fluorescence-based protein disaggregation assays in vitro as well as in cells; construction, setup, validation and operation of Sample Management, assay miniaturization, automation and High-Throughput Screening methods; develop skills in a BSL2 and 3 environment; and be part of a motivated and highly innovative team doing cutting edge science. He/She will participate in compound library selection, compound resupply, and validation of compounds in relevant models, i.e. neuronal models differentiated from patient-derived induced pluripotent stem cells. The Drug Discovery center is integral to Berkeley's efforts to enhance translational science capabilities, including proof-of-concept for new projects, investigation of tractability, startup formation and fundraising with the potential to help develop first-in-class therapeutics for unmet medical needs.
Performs and supervises design, construction, setup, validation and operation of sample management and semi-automated to fully robotic integrated screening operation capabilities; uses functional Sample Management system and Data storage architecture, keeps systematic records. Helps develop fluorescence-based in vitro model systems to elicit protein unfolding and aggregate clearance, and other modalities based on project needs.
Transition of cellular aggregate clearance models to screening stage; researches solutions to technical problems, interfaces with vendors.
Execution of small molecule screening campaigns, including compound selection and dispense, data analysis, compound resupply
Effectively communicates results, issues and suggestions for future directions to the team
Interface with faculty, researchers and students - advise on screening, assay development; guide assay automation and miniaturization
Stay up to date on screening technologies and approaches and provide expert guidance for the campus; provide expert resource in setting up novel screens and conducting technology development
Expertise with biochemical and microscopy assays
Solid understanding of enzymology and assay conditions
Detail-oriented, reliably execute assays and make reagents
Demonstrated organizational and decision-making abilities to prioritize competing work assignments in order to meet deadlines while staying within budget and adhering to quality standards
Hands-on and methodical, organized and diligent
Self-motivated and takes initiative on tasks and projects.
Effective written and verbal communication, data analysis and presentation skills.
Ability to work in a collaborative manner; identify challenges and barriers and recommend resolutions.
Bachelor's Degree with suitable laboratory experience and/or equivalent experience/training.
Able to use data visualization software, databases and data retrieval tools (Tibco Spotfire, Abase etc)
Experience with Sample Management, programming languages
Interest in learning to write scripts for robots and/or experience
Interest in neurodegenerative diseases
Hardware engineering experience
Knowledge of robotic systems.
Salary & Benefits
This is an hourly paid position eligible for full UC Benefits. Hourly rate will be commensurate with experience within the range of $28.74 - $38.32
For information on the comprehensive benefits package offered by the University visit:
Please submit your cover letter and resume as a single attachment when applying.
This is a full-time, one-year contract position. Renewable with continued funding.
Conviction History Background
This is a designated position requiring fingerprinting and a background check due to the nature of the job responsibilities. Berkeley does hire people with conviction histories and reviews information received in the context of the job responsibilities. The University reserves the right to make employment contingent upon successful completion of the background check.
Equal Employment Opportunity
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
The University of California was chartered in 1868 and its flagship campus - envisioned as a "City of Learning" - was established at Berkeley, on San Francisco Bay. Today the world's premier public university and a wellspring of innovation, UC Berkeley occupies a 1,232 acre campus with a sylvan 178-acre central core. From this home its academic community makes key contributions to the economic and social well-being of the Bay Area, California, and the nation.