Modeling the influence of advanced glycation end-products in aging and neurodegeneration using C. elegans and mice
This position involves studying the role of glucose and Advanced Glycation Endproducts (AGEs) in aging and age-related diseases using C. elegans, mice and IPS derived cells.We propose to examine the mechanisms involved in synthesis and detoxification of Advanced Glycation Endproducts (AGEs).
ABOUT THE LAB
The Kapahi Laboratory at the Buck Institute focuses on identifying and characterizing the mechanisms by which nutrients modulate aging and age-related diseases. To achieve this, we use an interdisciplinary approach combining genetic, pharmacological, biochemical and genomic approaches in invertebrate model systems C. elegans, D. melanogaster and mammalian cells. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity and neurodegeneration.
Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. "A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive alpha-Dicarbonyl Detoxification." Curr Biol 26, no. 22 (2016): 3014-3025. PMC5135008
Zee, T., Bose, N., Zee, J., Beck, J. N., Yang, S., Parihar, J., Yang, M., Damodar, S., Hall, D., O'Leary, M. N., Ramanathan, A., Gerona, R. R., Killilea, D. W., Chi, T., Tischfield, J., Sahota, A., Kahn, A., Stoller, M. L. and Kapahi, P. "alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria." Nat Med 23, no. 3 (2017): 288-290.
Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., Ramanathan, A., Sehgal, A., Giebultowicz, J. M. and Kapahi, P. "Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila." Cell Metab 23, no. 1 (2016): 143-54. PMC4715572
Chen D, Melov S, Kapahi P. Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans. Cell Reports, 2013
RogersAN, Chen D, Czerwieniec G, McCollG, Felkey K, Melov S, GibsonB, HubbardA, LithgowGJ, Kapahi P. Post-transcriptional remodeling of longevity and stress response gene expression by inhibition of eIF-4G. Cell Metabolism, 2011
WE’RE LOOKING FOR
Candidates who have completed their PhD
Prior experience in worm genetics is a plus
Candidates wishing to progress towards an independent career will receive training in specific area(s) of research
Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, nonprofit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer. We are an equal opportunity employer and strive to create an atmosphere where diversity of identity, experience, and background are welcomed, valued, and supported. Candidates who contribute to this diversity are strongly encouraged to apply.