A Senior Research Scientist - Basic Life position is available in the laboratory of Oliver Dorigo MD, PhD, Director of the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology at the Stanford University School of Medicine. The laboratory focuses on understanding the complex immune tumor microenvironment in ovarian cancer, with a particular interest in the role of macrophages. Utilizing our findings, we design and test new immunotherapeutic strategies in cell and mouse models.
The complex tumor microenvironment in gynecologic cancers plays a major role in modulating anti-tumor immune responses. The interaction of cancer cells with the diverse spectrum of immune effector cells has an important impact on the efficacy of standard chemotherapy and novel immunotherapy approaches. Within the tumor niche, tumor-associated macrophages (TAMs) promote tumor growth and mediate immune-suppression thereby effecting treatment responses. We outline clinical strategies that directly target TAMs, including inhibiting macrophage differentiation, preventing recruitment of monocytes to the tumor, enhancing phagocytosis and immune checkpoint blockade.
The primary role of the Senior Basic Life Research Scientist will be to supervise and guide the research activities of up to five members of the laboratory, including technicians, students and postdoctoral fellows. Responsibilities include generating and/or expanding hypotheses to further elucidate the role of macrophages in ovarian cancer, designing and interpretating experiments for research projects, and conducting experiments involving complex in-vitro assays, flow cytometry staining and sorting, microscopy and animal studies. In addition, the Senior Research Scientist - Basic Life is expected to review and present relevant literature. The candidate will participate in collaborative research projects with various investigators at Stanford University. The Senior Research Scientist - Basic Life will work closely with the Principal Investigator Oliver Dorigo, and based on prior experience and qualifications will have autonomy to make independent decisions. The candidate is required to have strong presentation and writing skills to participate in local, national and international conferences.
PhD in biological sciences preferably related to the immune biology of cancer.
Minimum of five years of research laboratory experience following completion of PhD.
Proficiency with cell culture, cellular and molecular biology techniques, and animal tumor models.
Ability to work independently and as part of a research team.
Experience in supervising or mentoring junior lab members.
Strong presentation and writing skills.
Cover letter and at least 3 references are required.
Strong publication record in high impact journals.
Proficiency with confocal microscopy and high-dimensional flow cytometry (8+ colors).
About the Department of Obstetrics and Gynecology: Our mission is to provide sustained leadership in scientific investigation, outstanding patient care, and education by training the future leaders of our specialty. Our faculty is committed to the highest level of basic and clinical research in Obstetric & Gynecologic science. In particular, we are focused on innovative translational medicine; bringing scientific results from the bench to the bedside.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University's research, teaching and clinical missions.
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.