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Life Science Research Professional 3 - Lab Manager
Stanford University
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Posted: 20-May-22 Location: Stanford, California Type: Full-time Salary: Open Categories: Staff/Administrative
Internal Number: 85727 The Department of Genetics at Stanford University is seeking a Senior Research Scientist (Life Science Research Professional 3) focusing on genome editing, molecular biology, biochemistry, and/or genomics technology development to join the Engreitz Laboratory to map the regulatory wiring of the human genome to discover genetic mechanisms of heart diseases. The Engreitz Lab will launch at the Stanford University Department of Genetics and Children's Heart Center starting in 2020. The ideal candidate will join as soon as possible. Candidate will have the option to train with the Engreitz group at the Broad Institute in Cambridge, MA during a transition period in 2020. Lab overview: DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions -- if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. bioRxiv 2019). We invent new tools combining experimental and computational genomics, biochemistry, molecular biology, and human genetics to assemble regulatory maps of the human genome and uncover biological mechanisms of heart disease. We are looking for creative and passionate people at any stage in their careers. The research scientist will work closely with the PI to invent new molecular and genomic technologies, apply these technologies at large scale to understand the regulatory wiring of the genome, and mentor and train other members in the Engreitz Labory. Specific projects include: to develop CRISPR-based tools to map the functions of thousands of noncoding variants and enhancers; chart enhancer-promoter regulation in every cell type and state in the developing heart using single-cell CRISPR and epigenomic tools; understand enhancer-promoter biochemical specificity by synthetic DNA engineering of millions of enhancer-promoter combinations; and develop novel computational models to understand genetic regulation of heart disease by noncoding variants. For more information and recent work, see www.engreitzlab.org. The Engreitz Laboratory is a dynamic, interdisciplinary workplace that will provide unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems. The candidate for this position should have hands-on experience in molecular biology, genomics, and cellular assay development; experience with quantitative data analysis; curiosity in research and creativity in problem-solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients. Duties include:
Grade: H FTE: 100% * - Other duties may also be assigned.
EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and four years of relevant work experience; or Master's degree in a related scientific field and two years relevant experience; or PhD in related science field. KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
CERTIFICATIONS & LICENSES: None PHYSICAL REQUIREMENTS*:
WORKING CONDITIONS:
WORK STANDARDS (from JDL):
Additional Information
About Stanford University
Why work at Stanford?Stanford University has changed the world, over and over again.We are one of Silicon Valley's largest employers - and also one of the most unique. Our mission is to educate future leaders and promote interdisciplinary, world-class research and teaching. This passion makes Stanford an intensely creative, rewarding, and challenging place to work. At the same time, our traditions of respect and collaboration sustain a humane, supportive environment in which to pursue your life and your career.At Stanford you'll work with bright, diverse, dedicated people. You'll find encouragement to learn and grow. You'll enjoy excellent benefits and an outstanding environment. How will it change you?
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