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Sr. Research Scientist-Basic Life Science (Fixed-Term)

Stanford University

Details

Posted: 20-May-22

Location: Stanford, California

Type: Full-time

Salary: Open

Categories:

Staff/Administrative

Internal Number: 86893

**Fixed-Term Position**

The Fantl Lab at Stanford University School of Medicine studies human tumors with translational endpoints with the over-arching goal to dramatically shorten the time from bench to bedside. We use multi-parameter single cell technologies (mass cytometry/CyTOF and imaging) to comprehensively characterize human tumors on a cell-by-cell basis; specifically ovarian, kidney and prostate. Two areas of focus of the lab are tumor-immune interactions and the DNA-damage response. To date, work from our and other labs have demonstrated that multi-parameter single cell technologies have provided an unprecedented level of mechanistic detail not only revealing further unappreciated complexity of tumor ecosystems, but directing us toward more meaningful novel biomarkers. These are highly likely to guide far more beneficial treatment regimens for cancer patients. We work collaboratively in multidisciplinary teams. We synergize with bioinformaticians for integrating large datasets and clinicians to ensure the acquisition of tumor tissue and also to keep us on track as to what will make a difference to patients.

We are seeking a highly motivated, committed and creative Senior Scientist to oversee the general running of the lab. The preferred candidate is an immunologist and/or cancer biologist. The candidate will be adept at working with multiple assay formats, assay troubleshooting, problem-solving and data analysis/interpretation in addition to driving multiple research projects.

He/she will apply CyTOF to clinically annotated tumors and blood samples and use integrative computational tools to provide novel insight about disease mechanism and develop potential biomarkers. Projects include, but are not limited to: i) therapeutic resistance in ovarian cancer ii) predictive biomarkers for women with ovarian cancer likely to respond to PARPis iii) understanding the role of defects in BRCA1/2 and other DNA damage response genes with the tumor immune infiltrate in ovarian cancer iv) predicting response of renal cell carcinoma patients to immunotherapy v) determining which men with localized prostate cancer will develop aggressive disease.

Educational Requirements:

PhD Biological Sciences, Immunology, Molecular Biology, Genetics, or related field of study.

Skills required:

Flow cytometry and mass cytometry, processing clinical samples especially those obtained from prospective clnical trials, cell culture; cell lines and primary cells, transfection, immunohistochemistry, general techniques in molecular biology, knowledge of rudimentary data analysis. Must have exemplary organizational skills, clear written and oral communication skills, ability to learn new techniques and be familiar with day-to-day running of lab.

Contact information: wjfantl@stanford.edu

"StanfordUniversity is an equal opportunity employer and is committed to increasing thediversity of its faculty and academic staff. It welcomes nominations of andapplications from women and members of minority groups, as well as others whowould bring additional dimensions to the University's research, teaching andclinical missions."

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About Stanford University

Why work at Stanford?Stanford University has changed the world, over and over again.We are one of Silicon Valley's largest employers - and also one of the most unique. Our mission is to educate future leaders and promote interdisciplinary, world-class research and teaching. This passion makes Stanford an intensely creative, rewarding, and challenging place to work. At the same time, our traditions of respect and collaboration sustain a humane, supportive environment in which to pursue your life and your career.At Stanford you'll work with bright, diverse, dedicated people. You'll find encouragement to learn and grow. You'll enjoy excellent benefits and an outstanding environment. How will it change you?

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